The 2010 United States Senate election in North Carolina was held on November 2, 2010. The filing deadline for the primaries was February 26; the primaries were held on May 4, with a Democratic primary runoff held on June 22. Incumbent Republican U.S. Senator Richard Burr won re-election to a second term. Burr is the first incumbent to win re-election for this seat since Sam Ervin's last re-election in 1968.

The 2004 United States Senate election in North Carolina was held on November 2, 2004. Incumbent Democratic U.S. Senator John Edwards decided to retire from the Senate after one term in order to run unsuccessfully for the 2004 Democratic Party presidential nomination, and become his party's vice presidential nominee. Republican Richard Burr won the open seat, making it the fifth consecutive election in which partisan control of the seat changed.