The 2010 United States Senate election in Utah took place on November 2, 2010, along with other midterm elections throughout the United States. Incumbent Republican U.S. Senator Bob Bennett was seeking re-election to a fourth term, but lost renomination at the Republican Party's state convention. Mike Lee proceeded to win the Republican primary against Tim Bridgewater and the general election against Democrat Sam Granato. As of 2024, this is the most recent U.S. Senate election in which a political party held the seat after denying renomination to the incumbent senator.

Michael Shumway Lee is an American lawyer and politician serving as the senior United States senator from Utah, a seat he has held since 2011. A member of the Republican Party, Lee became Utah's senior senator when Orrin Hatch retired from the Senate in 2019 and dean of Utah's congressional delegation when Rob Bishop retired from the House of Representatives in 2021.