During the late afternoon and early evening of April 27, 2011, a violent, high-end EF4 multiple-vortex tornado destroyed portions of Tuscaloosa and Birmingham, Alabama, as well as smaller communities and rural areas between the two cities. It is one of the costliest tornadoes on record, and was one of the 360 tornadoes in the 2011 Super Outbreak, the largest tornado outbreak in United States history. The tornado reached a maximum path width of 1.5 miles (2.4 km) during its track through Tuscaloosa, and again when it crossed I-65 north of Birmingham, attaining estimated wind speeds of 190 mph (310 km/h) shortly after passing through the city. It then went on to impact parts of Birmingham at high-end EF4 intensity before dissipating. This was the third tornado to strike the city of Tuscaloosa in the past decade, and the second in two weeks.

The 2011 Hackleburg–Phil Campbell tornado was an extremely deadly, violent, and long-tracked EF5 wedge tornado that devastated several towns in rural northern Alabama, before tearing through the northern suburbs of Huntsville and causing damage in rural portions of southern Tennessee on the afternoon and early evening of April 27, 2011. It was the deadliest tornado of the 2011 Super Outbreak, the largest tornado outbreak in United States history. The tornado reached a maximum width of 1.25 miles (2.01 km) and was estimated to have had peak winds of 210 mph (340 km/h). The tornado killed 72 people, making it the deadliest tornado in Alabama history, and injured at least 145 others. At the time, it was the deadliest tornado to strike the United States since the 1955 Udall, Kansas, tornado.