The year 2011 saw a number of significant events in spaceflight, including the retirement of NASA's Space Shuttle after its final flight in July 2011, and the launch of China's first space station module, Tiangong-1, in September. A total of 84 orbital launches were conducted over the course of the year, of which 78 were successful. Russia, China and the United States conducted the majority of the year's orbital launches, with 35, 19 and 18 launches respectively; 2011 marked the first year that China conducted more successful launches than the United States. Seven crewed missions were launched into orbit during 2011, carrying a total of 28 astronauts to the International Space Station. Additionally, the Zenit-3F and Long March 2F/G carrier rockets made their maiden flights in 2011, while the Delta II Heavy made its last.

STS-133 was the 133rd mission in NASA's Space Shuttle program; during the mission, Space Shuttle Discovery docked with the International Space Station. It was Discovery's 39th and final mission. The mission launched on February 24, 2011, and landed on March 9, 2011. The crew consisted of six American astronauts, all of whom had been on prior spaceflights, headed by Commander Steven Lindsey. The crew joined the long-duration six person crew of Expedition 26, who were already aboard the space station. About a month before lift-off, one of the original crew members, Tim Kopra, was injured in a bicycle accident. He was replaced by Stephen Bowen.