The 60th Annual Mobil 1 Twelve Hours of Sebring was a 12-hour automobile endurance race for teams of three drivers each fielding sports prototype and grand touring cars held on March 17, 2012 at the Sebring International Raceway in Sebring, Florida before more than 90,000 spectators. It was the 60th 12 Hours of Sebring and the first round of both the 2012 FIA World Endurance Championship (WEC) and the 2012 American Le Mans Series (ALMS). Le Mans Prototype 1 (LMP1), Le Mans Prototype 2 (LMP2), Le Mans Prototype Challenge (LMPC), Le Mans Grand Touring Endurance (LMGTE), and Grand Touring Challenge (GTC) cars competed in the race.

The 12 Hours of Sebring is an annual motorsport endurance race for sports cars held at Sebring International Raceway, on the site of the former Hendricks Army Airfield World War II air base in Sebring, Florida, US. In the past, this race has been a round of the now defunct World Sportscar Championship, IMSA GT Championship and American Le Mans Series. In 2012, the race was the opening event of the FIA World Endurance Championship in a one off race before being returned back to the American Le Mans Series for 2013. Starting in 2014, the event became the second round of the WeatherTech SportsCar Championship.