The 2012 NCAA Division I women's basketball tournament began March 17 and concluded April 3, 2012. The Final Four was played at Pepsi Center in Denver. For only the second time in history, and the first time since 1989, all four of the number one seeds made it to the Final Four. Baylor won its second national championship, defeating Notre Dame 80–61 in the championship game. They were the only team to win 40 straight games in a season until Connecticut matched it in 2014.

Ball Arena is a multi-purpose indoor arena located in Denver, Colorado. It is situated at Speer Boulevard, a main thoroughfare in downtown Denver, and is served by two nearby exits off Interstate 25. A light rail station is on the western side of the complex. Opened in 1999, it is the home arena of the Denver Nuggets of the National Basketball Association (NBA), the Colorado Avalanche of the National Hockey League (NHL), and the Colorado Mammoth of the National Lacrosse League (NLL).