The 2012 United States Senate election in Minnesota took place on November 6, 2012, concurrently with the U.S. presidential election as well as other elections to the United States Senate and House of Representatives as well as various state and local elections. Incumbent Democratic–Farmer–Labor U.S. Senator Amy Klobuchar faced Republican State Representative Kurt Bills. Klobuchar was reelected in a landslide, defeating Bills by almost one million votes and carrying all but two of the state's 87 counties by double digits. This election marked the first time since 1996 that an incumbent Democratic senator was re-elected and the first time since 1976 that an incumbent Democratic senator was re-elected to this seat.

Minnesota's 2nd congressional district covers the south Twin Cities metro area and contains all of Scott, Dakota, and Le Sueur counties. It also contains part of northern and eastern Rice County including the city of Northfield, as well as southern Washington County including the city of Cottage Grove. Lakeville and Eagan are the largest cities in the district. Historically, for many decades in the mid 20th century the 2nd congressional district covered the southwest corner of the state, while the 1st congressional district covered most of this part of the state.