The 2012 United States Senate election in Wyoming took place on November 6, 2012, alongside a U.S. presidential election as well as other elections to the United States Senate and House of Representatives and various state and local elections. Incumbent Republican U.S. Senator John Barrasso won re-election to a first full term.

John Anthony Barrasso III is an American physician and politician serving as the senior United States senator from Wyoming, a seat he has held since 2007. A member of the Republican Party, he served in the Wyoming State Senate from 2003 to 2007. As Chair of the Senate Republican Conference since 2019, he is the third-ranking Senate Republican.