The 2012 Vanderbilt Commodores football team represented Vanderbilt University during the 2012 NCAA Division I FBS football season. The Commodores played their six home games at Vanderbilt Stadium at Dudley Field in Nashville, Tennessee, which has been Vanderbilt football's home stadium since 1922. The team's head coach was James Franklin, who is in his second year at Vanderbilt. Vanderbilt has been a member of the Southeastern Conference (SEC) since the league's inception in 1932, and has participated in the conference's Eastern Division since its formation for the 1992 season. On November 11, 2012 Vandy became bowl eligible in back to back years for the first time in its 123-year football history. This was the first time since 1935 that Vandy won five SEC games in a year and the first time in 30 years that they won at home against Tennessee. Vanderbilt finished the year with the longest current SEC winning streak. For the first time since 1948, Vanderbilt finished the season with a top 25 ranking.

The 2012 Arkansas Razorbacks football team represented the University of Arkansas during the 2012 NCAA Division I FBS football season. The Razorbacks played their home games at Donald W. Reynolds Razorback Stadium in Fayetteville and War Memorial Stadium in Little Rock, Arkansas. They were a member of the Western Division of the Southeastern Conference.