On March 12, 2014, an explosion occurred at 9:31 a.m. in the East Harlem neighborhood of Manhattan in New York City, United States. The explosion leveled two apartment buildings located just north of 116th Street at 1644 and 1646 Park Avenue, killing eight people, injuring at least 70 others, and displacing 100 families. City officials initially pointed to a gas leak as the cause of the blast. In June 2015, the National Transportation Safety Board (NTSB) blamed the explosion on failures by Consolidated Edison and the city. The NTSB also agreed to review Whistleblower Gas Explosion Audit Findings from the 2009 Floral Park Queens gas explosion as part of their East Harlem Gas Explosion Investigation. The NTSB were unable to resolve these hazards found with merit by the New York State Public Service Commission (NYSPSC) and they remain a Public Safety Hazard today.

East Harlem, also known as Spanish Harlem or El Barrio, is a neighborhood of Upper Manhattan in New York City, north of the Upper East Side and bounded by 96th Street to the south, Fifth Avenue to the west, and the East and Harlem Rivers to the east and north. Despite its name, it is generally not considered to be a part of Harlem proper, but it is one of the neighborhoods included in Greater Harlem.