The 2015–16 Arizona Wildcats men's basketball team represented the University of Arizona during the 2015–16 NCAA Division I men's basketball season. The team was led by seventh-year head coach Sean Miller, and played their home games at McKale Center in Tucson, Arizona as a member of the Pac-12 Conference. They finished the season 25–9, 12–6 in Pac-12 play to tie with California for third place. They defeated Colorado in the quarterfinals of the Pac-12 tournament to advance to the semifinals where they lost to Oregon. Arizona received an at-large bid to the fourth-straight NCAA tournament, the program's 31st appearance, as a 6-seed in the South Region. They lost in the first round to Wichita State.

Sean Edward Miller is an American college basketball coach who currently serves as head coach of the Xavier Musketeers. He previously held that position from 2004 to 2009, after which he took the head coach position at the Arizona Wildcats, which he held until being fired in 2021.