The 2015–16 Duke Blue Devils men's basketball team represented Duke University during the 2015–16 NCAA Division I men's basketball season. The Blue Devils were led by 36th year head coach and Hall of Fame member Mike Krzyzewski. The team played its home games at Cameron Indoor Stadium in Durham, North Carolina as members of the Atlantic Coast Conference. They finished the season 25–11, 11–7 in ACC play to finish in a tie for fifth place. They defeated NC State in the second round of the ACC tournament to advance to the quarterfinals where they lost to Notre Dame. They received an at-large bid to the NCAA tournament where they defeated UNC Wilmington and Yale to advance to the Sweet Sixteen where they lost to Oregon.

Michael William Krzyzewski, nicknamed "Coach K", is an American former college basketball coach. He served as the head coach at Duke University from 1980 to 2022, during which he led the Blue Devils to five national titles, 13 Final Fours, 15 ACC tournament championships, and 13 ACC regular season titles. Among men's college basketball coaches, only UCLA's John Wooden has won more NCAA championships (10). Krzyzewski is widely regarded as one of the greatest college basketball coaches of all time.