The 2015–16 Michigan State Spartans men's basketball team represented Michigan State University in the 2015–16 NCAA Division I men's basketball season. The Spartans, led by 21st-year head coach Tom Izzo, played their home games at the Breslin Center and were members of the Big Ten Conference. They finished the season 29–6, 13–5 in Big Ten play to finish in second place. They defeated Ohio State, Maryland, and Purdue to win the Big Ten tournament. As a result, they received the conference's automatic bid to the NCAA tournament, their 19th straight NCAA tournament appearance. As the No. 2 seed in the Midwest region, they were upset by No. 15 seed Middle Tennessee in what is considered to be one of the biggest upsets in NCAA tournament history.

Thomas Michael Izzo ; born January 30, 1955) is an American college basketball coach who has been the head coach at Michigan State University since 1995. On April 4, 2016, Izzo was elected to the Naismith Basketball Hall of Fame.