The 2015–16 Purdue Boilermakers men's basketball team represented Purdue University. Their head coach was Matt Painter, in his 11th season with the Boilers. The team played its home games in Mackey Arena in West Lafayette, Indiana and were members of the Big Ten Conference. They finished the season 26–9, 12–6 in Big Ten play to finish in a four-way tie for third place. As the No. 4 seed in the Big Ten tournament, they defeated Illinois and Michigan to advance to the championship game. In a closely fought championship game, they lost to Michigan State 66–62. The Boilermakers received an at-large bid to the NCAA tournament as a No. 5 seed, their second straight trip to the Tournament. In the First Round, they were upset by No. 12-seed Little Rock 85–83 in double overtime.

Matthew Curtis Painter is an American basketball coach and former player, who is the current and 19th head coach of the Purdue Boilermakers, serving in that role since 2005. He played college basketball at Purdue from 1989 to 1993. He was also the head coach of the Southern Illinois Salukis from 2003 to 2004.