The 2015–16 Xavier Musketeers men's basketball team represented Xavier University during the 2015–16 NCAA Division I men's basketball season. Led by seventh year head coach Chris Mack, they played their games at the Cintas Center and were third year members of the Big East Conference. They finished the season 28–6, 14–4 in Big East play to finish in second place. They defeated Marquette in the quarterfinals of the Big East tournament to advance to the semifinals where they lost to Seton Hall. They received an at-large bid to the NCAA tournament where they received a #2 seed. They defeated Weber State in the First Round to advance to the Second Round where they lost to Wisconsin.

Christopher Lee Mack is an American college basketball coach who is currently the head coach at the College of Charleston. He formerly served as head coach for the University of Louisville and Xavier University.