The 2015 Bojangles' Southern 500, the 59th running of the event that traces its lineage to the 1957 Rebel 300, was a NASCAR Sprint Cup Series race held on September 6, 2015, at Darlington Raceway in Darlington, South Carolina. Contested over 367 laps on the 1.366 mile (2.198 km) egg-shaped speedway, it was the 25th race of the 2015 NASCAR Sprint Cup Series season. Carl Edwards won the race, the 25th of his career. Brad Keselowski finished second. Denny Hamlin, Joey Logano and Kevin Harvick rounded out the top five.

The 2015 NASCAR Sprint Cup Series was the 67th season of professional stock car racing in the United States and the 44th modern-era Cup season. The season began at Daytona International Speedway with the Sprint Unlimited exhibition race, the Budweiser Duels, and the Daytona 500. The season ended with the Ford EcoBoost 400 at Homestead-Miami Speedway. Kyle Busch won the championship, despite missing the first third of the season due to severe leg injuries suffered in an Xfinity Series race at Daytona. Busch also became the first Toyota driver to win a Cup championship. Despite not running the full season, Brett Moffitt was named Rookie of the Year.