On April 29, 2015, the Baltimore Orioles defeated the Chicago White Sox 8–2 in the first crowdless game ever played by Major League Baseball teams. The lack of crowds was due to civil unrest in Baltimore following the death of Freddie Gray, an African-American man who was critically injured while in police custody 10 days earlier. With all the civil unrest, there were insufficient security resources available for the game. The previous two games in the teams' series had been postponed, but the remaining game could neither be moved to another venue on short notice nor made up later in the season, so the decision was made to play the game at Camden Yards without allowing any fans to attend. The scheduled evening start time was also moved up to the afternoon for security reasons.

On April 12, 2015, Baltimore Police Department officers arrested Freddie Gray, a 25-year-old African American resident of Baltimore, Maryland. Gray's neck and spine were injured while he was in a police vehicle and he went into a coma. On April 18, there were protests in front of the Western district police station. Gray died on April 19.