The 2015 Coca-Cola 600, the 56th running of the event, was a NASCAR Sprint Cup Series race held on May 24, 2015 at Charlotte Motor Speedway in Concord, North Carolina. Contested over 400 laps on the 1.5 mile (2.42 km) asphalt speedway, it was the 12th race of the 2015 NASCAR Sprint Cup season. Carl Edwards won the race, his first of the season and first with Joe Gibbs Racing. Greg Biffle finished second. Dale Earnhardt Jr. finished third. Matt Kenseth and Martin Truex Jr. rounded out the top five.

The 2015 NASCAR Sprint Cup Series was the 67th season of professional stock car racing in the United States and the 44th modern-era Cup season. The season began at Daytona International Speedway with the Sprint Unlimited exhibition race, the Budweiser Duels, and the Daytona 500. The season ended with the Ford EcoBoost 400 at Homestead-Miami Speedway. Kyle Busch won the championship, despite missing the first third of the season due to severe leg injuries suffered in an Xfinity Series race at Daytona. Busch also became the first Toyota driver to win a Cup championship. Despite not running the full season, Brett Moffitt was named Rookie of the Year.