The 2015 Milan–San Remo was a one-day cycling classic that took place in Italy on 22 March. The race was the 106th edition of the Milan–San Remo. It was the fourth of the 28 races on the Union Cycliste Internationale's (UCI) 2015 World Tour and the first of them to be a one-day race. It was also the first of the 2015 cycling monuments, the five most important one-day races of the year. The defending champion was Alexander Kristoff, who won the previous year's race in a sprint.

Milan–San Remo, also called "The Spring classic" or "La Classicissima", is an annual road cycling race between Milan and Sanremo, in Northwest Italy. With a distance of 298 km it is the longest professional one-day race in modern cycling. It is the first major classic race of the season, usually held on the third Saturday of March. The first edition was held in 1907.