The 2016 Amstel Gold Race was a one-day classic cycling race that took place in the Limburg region of the Netherlands on 17 April 2016. It was the 51st edition of the Amstel Gold Race and the eleventh event of the 2016 UCI World Tour. It was also the first of the Ardennes classics, although it is technically not in the Ardennes region. The race took place over a 258-kilometre (160 mi) route that starts in Maastricht and ends in Berg en Terblijt on the outskirts of Valkenburg. The key difficulty in the race came from the 34 short but steep climbs. The central climb, the Cauberg, was crossed four times, with 1.8 kilometres (1.1 mi) between the final summit and the finish line. The favourites for victory in the race included the three-time winner Philippe Gilbert (BMC), the defending champion Michał Kwiatkowski (Sky), and Simon Gerrans and Michael Matthews.

The Amstel Gold Race is a one-day classic road cycling race held annually since 1966 in the province of Limburg, Netherlands. It traditionally marks the turning point of the spring classics, with the climbers and stage racers replacing the cobbled classics riders as the favourites.