The 2016 Brickyard 400, branded as Crown Royal presents the Combat Wounded Coalition 400 at the Brickyard, was a NASCAR Sprint Cup Series stock car race held on July 24, 2016 at Indianapolis Motor Speedway in Speedway, Indiana. As the 23rd running of the Brickyard 400, contested over 170 laps—extended from 160 laps due to an overtime finish, on the 2.5-mile (4.0 km) speedway, it was the 20th race of the 2016 NASCAR Sprint Cup Series.

The 2016 NASCAR Sprint Cup Series was the 68th season of professional stock car racing in the United States and the 45th modern-era Cup series season. The season began at Daytona International Speedway with the Sprint Unlimited, the Can-Am Duel and the Daytona 500. The season ended with the Ford EcoBoost 400 at Homestead-Miami Speedway. Jimmie Johnson of Hendrick Motorsports won his seventh drivers' championship, tying Richard Petty and Dale Earnhardt for most all-time. Toyota won the manufacturer's championship, becoming the first manufacturer to win the manufacturer's championship other than Chevrolet since 2002.