The 2016 Major League Soccer All-Star Game, the 21st annual Major League Soccer All-Star Game, took place on July 28, 2016 at Avaya Stadium, the home of the San Jose Earthquakes. The game was televised live on ESPN and Univision in the United States, and on TSN and RDS in Canada. The game featured the MLS All-Star team playing English side Arsenal, with the match being a preseason friendly for Arsenal as part of their tour of California.

PayPal Park is a soccer-specific stadium in San Jose, California. It is the home stadium of the San Jose Earthquakes of Major League Soccer (MLS) and Bay FC of the National Women's Soccer League (NWSL). The stadium is located on the Airport West site next to the San Jose International Airport.