The 2016 Michigan Wolverines football team represented the University of Michigan in the sport of college football during the 2016 NCAA Division I FBS football season. The Wolverines played in the East Division of the Big Ten Conference and played their home games at Michigan Stadium in Ann Arbor, Michigan. Michigan was led by head coach Jim Harbaugh, who was in his second season.

The 2016 Florida State Seminoles football team represented Florida State University in the sport of American football during the 2016 NCAA Division I FBS football season. The Seminoles competed in the Atlantic Division of the Atlantic Coast Conference and were led by seventh-year head coach Jimbo Fisher. Home games were played at Doak Campbell Stadium in Tallahassee, Florida.