The 2016 NFL draft was the 81st annual draft of National Football League (NFL) franchises to select newly eligible American football players. As in 2015, the draft took place at the Auditorium Theatre and Grant Park in Chicago. The draft began on Thursday, April 28 with the first round, and ended on Saturday, April 30. The Tennessee Titans, the team with the fewest wins in the NFL for the 2015 season, traded the right to the top pick in the draft to the Los Angeles Rams, the first time the top pick was traded before the draft since 2001 when the San Diego Chargers traded their first pick to the Atlanta Falcons. Ohio State became the second school to have three players drafted in the top ten and to have five players drafted in the first round.

The 2015 NFL draft was the 80th annual meeting of National Football League (NFL) franchises to select newly eligible football players. It took place in Chicago at the Auditorium Theatre and in Grant Park, from April 30 to May 2. This was the first NFL draft held outside New York City in fifty years. The 2015 NFL draft was the first to feature a companion outdoor fair, where fans would be able to see the Commissioner during the selection on the Auditorium Theatre stage from across the street in the park; this area was called Draft Town. The Tampa Bay Buccaneers held the right to select first because they had the league's worst record in the previous season. The Arizona Cardinals made the final pick in the draft, commonly called Mr. Irrelevant.