The St. Louis Cardinals 2016 season was the 135th for the Major League Baseball (MLB) franchise in St. Louis, Missouri, the 125th season in the National League (NL), and the 11th at Busch Stadium III. They entered the season having won a major-league best 100 games, as three-time defending National League Central champions, and with five consecutive playoff appearances. Forbes magazine estimated the value of the club to be $1.6 billion in 2016, making it the seventh-most valuable franchise in MLB. The Cardinals were eliminated from playoff contention following the San Francisco Giants' 7–1 victory over the Los Angeles Dodgers on Sunday, October 2. This was the first time the Cardinals failed to make the playoffs since 2010.

Brayan Eduardo Peña is a Cuban-American former professional baseball catcher. He previously played in Major League Baseball (MLB) for the Atlanta Braves, Kansas City Royals, Detroit Tigers, Cincinnati Reds and St. Louis Cardinals. He is currently the Manager of the Detroit Tigers Class A team West Michigan Whitecaps.