The 2016 United States Senate election in Alaska was held on November 8, 2016, to elect a member of the United States Senate to represent the State of Alaska, concurrently with the 2016 U.S. presidential election, as well as other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections.

Lisa Ann Murkowski is an American attorney and politician serving as the senior United States senator representing Alaska, having held that seat since 2002. She is the first woman to represent Alaska in the Senate and the Senate's second-most senior Republican woman, after Susan Collins of Maine. She became dean of Alaska's congressional delegation upon Representative Don Young's death.