The 2016 United States Senate election in Missouri was held on November 8, 2016, to elect a member of the United States Senate to represent the State of Missouri. It was held concurrently with the 2016 U.S. presidential election, as well as other elections to the United States Senate in other states, elections to the United States House of Representatives, and various state and local elections. The primaries were held on August 2.

Roy Dean Blunt is an American politician who served as a United States senator from Missouri from 2011 to 2023. A member of the Republican Party, he previously served as the 33rd Missouri Secretary of State (1985–1993) and U.S. Representative for Missouri's 7th congressional district (1997–2011).