The 2016 United States Senate election in North Carolina was held November 8, 2016, to elect a member of the United States Senate to represent the State of North Carolina, concurrently with the 2016 U.S. presidential election, as well as other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections. Primary elections were held March 15.

Deborah Ross is an American lawyer and politician who has served as the U.S. representative for North Carolina's 2nd congressional district since 2021. Her district is based in Raleigh. A member of the Democratic Party, Ross served as a member of the North Carolina House of Representatives from 2003 to 2013, representing the state's 38th and then 34th House district, including much of northern Raleigh and surrounding suburbs in Wake County.