The 2016 United States Senate election in Oklahoma was held November 8, 2016 to elect a member of the United States Senate to represent the State of Oklahoma, concurrently with the 2016 U.S. presidential election, as well as other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections. The primaries were held June 28.

James Paul Lankford is an American politician serving as the senior United States senator from Oklahoma. A member of the Republican Party, Lankford has represented Oklahoma in the U.S. Senate since 2015. Before his Senate service, he represented Oklahoma's 5th congressional district in the U.S. House of Representatives from 2011 to 2015.