The 2016 United States Senate election in Oregon was held November 8, 2016, to elect a member of the United States Senate to represent the State of Oregon, concurrently with the 2016 U.S. presidential election, as well as other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections.

Gilliam County is one of the 36 counties in the U.S. state of Oregon. As of the 2020 census, the population was 1,995, making it the third-least populous county in Oregon. The county seat is Condon. The county was established in 1885 and is named for Cornelius Gilliam, a colonel who commanded the forces of the provisional government of Oregon after the Whitman Massacre.