The 2016 United States Senate election in South Carolina was held on November 8, 2016, to elect a member of the United States Senate to represent the State of South Carolina, concurrently with the 2016 U.S. presidential election, as well as other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections. Both major parties held their primaries on June 14.

Timothy Eugene Scott is an American businessman and politician serving as the junior United States senator from South Carolina since 2013. A member of the Republican Party, he previously served as a Charleston city councilor, a state representative, and a U.S. Representative. He also worked in financial services before entering politics.