The 2018–19 Iowa State Cyclones men's basketball team represented Iowa State University during the 2018–19 NCAA Division I men's basketball season. The Cyclones were coached by Steve Prohm, who was in his fourth season at Iowa State. They played their home games at Hilton Coliseum in Ames, Iowa as members of the Big 12 Conference. They finished the season 23-12, finishing in 5th place. In the Big 12 tournament, they defeated Baylor, Kansas State, and Kansas to win the Big 12 tournament. They received an automatic bid as a 6th seed in the NCAA tournament where they were upset by 11th seed Ohio State in the First Round.

Steven Marshall Prohm is an American basketball coach who is in his second tenure as the head coach for Murray State men's basketball. Previously, he was the head coach at Iowa State University, a position he had held from 2015 to 2021. Prohm served in the same capacity at Murray State University from 2011 to 2015.