The 2018 Can-Am 500 was a Monster Energy NASCAR Cup Series race that was held on November 11, 2018, at ISM Raceway in Avondale, Arizona. Contested over 312 laps on the one mile (1.6 km) oval, it was the 35th race of the 2018 Monster Energy NASCAR Cup Series season, ninth race of the Playoffs, and final race of the Round of 8.

The 2018 Monster Energy NASCAR Cup Series was the 70th season of NASCAR professional stock car racing in the United States, and the 47th modern-era Cup series season. The season began at Daytona International Speedway with the Advance Auto Parts Clash, the Can-Am Duel qualifying races and the 60th running of the Daytona 500. The regular season ended with the Brickyard 400 on September 9, 2018. The playoffs ended with the Ford EcoBoost 400 at Homestead-Miami Speedway on November 18, 2018. Martin Truex Jr. was the defending champion, having won his first in the series.