The 2018 United States Senate election in Massachusetts took place on November 6, 2018. Incumbent Democratic U.S. Senator Elizabeth Warren ran for re-election to a second term. The candidate filing deadline was June 5, 2018, and the primary election was held on September 4, 2018.

Elizabeth Ann Warren is an American politician and former law professor who is the senior United States senator from Massachusetts, serving since 2013. A member of the Democratic Party and regarded as a progressive, Warren has focused on consumer protection, equitable economic opportunity, and the social safety net while in the Senate. Warren was a candidate in the 2020 Democratic Party presidential primaries, ultimately finishing third.