The 2018 United States Senate election in Missouri took place on November 6, 2018, to elect a member of the United States Senate to represent the State of Missouri, concurrently with other elections to the United States Senate, elections to the United States House of Representatives, and various state and local elections, including Missouri's quadrennial State Auditor election.

The 2018 United States Senate elections were held on November 6, 2018. Among the 100 seats, the 33 of Class 1 were contested in regular elections while 2 others were contested in special elections due to Senate vacancies in Minnesota and Mississippi. The regular election winners were elected to 6-year terms running from January 3, 2019, to January 3, 2025. Senate Democrats had 26 seats up for election, while Senate Republicans had 9 seats up for election.