The 2018 United States Senate election in West Virginia took place on November 6, 2018, to elect a member of the United States Senate to represent the State of West Virginia, concurrently with other elections to the United States Senate, elections to the United States House of Representatives, and various state and local elections.

Joseph Manchin III is an American politician and businessman serving as the senior United States senator from West Virginia, a seat he has held since 2010. Manchin was the 34th governor of West Virginia from 2005 to 2010 and the 27th secretary of state of West Virginia from 2001 to 2005. He became the state's senior U.S. senator when Jay Rockefeller left office in 2015 and has since been West Virginia's only congressional Democrat. Before entering politics, Manchin helped found and was the president of Enersystems, a coal brokerage company his family owns and operates.