The 2019 season was the Buffalo Bills' 60th overall, 50th in the National Football League (NFL), fifth full under the ownership of Terry and Kim Pegula and third under the head coach/general manager tandem of Sean McDermott and Brandon Beane.

Sean Michael McDermott is an American football coach who is the head coach for the Buffalo Bills of the National Football League (NFL). He began his NFL coaching career as an assistant for the Philadelphia Eagles in 2001, serving as defensive coordinator from 2009 to 2010, and was later the defensive coordinator of the Carolina Panthers from 2011 to 2016. Following his six seasons with the Panthers, which included a Super Bowl appearance in Super Bowl 50, he was hired in 2017 as the Bills head coach and assumed defensive coordinator duties in 2023.