The 2019 Copa CONMEBOL Sudamericana was the 18th edition of the CONMEBOL Sudamericana, South America's secondary club football tournament organized by CONMEBOL.

The CONMEBOL Sudamericana, also known as the Copa Sudamericana, is an annual international club football competition organized by CONMEBOL, the governing body of football in South America, since 2002. It is the second-most prestigious club competition in South American football. CONCACAF clubs were invited between 2004 and 2008. The CONMEBOL Sudamericana began in 2002, replacing the separate competitions Copa Merconorte and Copa Mercosur by a single competition. Since its introduction, the competition has been a pure elimination tournament with the number of rounds and teams varying from year to year.