The 2019 FC Cincinnati season was the club's debut season in Major League Soccer (MLS), and the fourth season of a team playing under the FC Cincinnati brand after three years in the lower-division United Soccer League. The club finished with a league worst 6–22–6 record in their inaugural MLS season, setting a league record for the most goals given up with 75. FC Cincinnati missed the playoffs.

The 2020 FC Cincinnati season was the club's second season in MLS, and the fifth season of a team playing under the FC Cincinnati brand after three years in the lower-division USL Championship. The club finished with a league worst 6–22–6 record in their inaugural MLS season in 2019, setting a league record for the most goals given up with 75. The 2020 season was the final year that FC Cincinnati played home matches at Nippert Stadium, as their new West End Stadium is scheduled to open in March 2021.