The 2019 Pennzoil 400 presented by Jiffy Lube was a Monster Energy NASCAR Cup Series race held on March 3, 2019, at Las Vegas Motor Speedway in Las Vegas. Contested over 267 laps on the 1.5 mi (2.4 km) asphalt intermediate speedway, it was the third race of the 2019 Monster Energy NASCAR Cup Series season.

The Pennzoil 400 presented by Jiffy Lube is a NASCAR Cup Series stock car race held annually at Las Vegas Motor Speedway in Las Vegas, Nevada. It is the first of two races at Las Vegas with the other one being the South Point 400 in the playoffs. The inaugural race was held in 1998. For several years, the race was sponsored by United Auto Workers and DaimlerChrysler. From its inception, the race was run at a distance of 400 miles (640 km) except 2009, which was 427 miles. The extra 27 miles in the 2009 race were added by the sponsors Carroll Shelby International.