The 2020–21 Egyptian Premier League, also known as The WE Egyptian Premier League for sponsorship purposes, was the 62nd season of the Egyptian Premier League, the top Egyptian professional league for association football clubs, since its establishment in 1948. The season started on 11 December 2020 and is concluded on 28 August 2021. Fixtures for the 2020–21 season was announced one week before the start of the competition.

The Egyptian Premier League, also known as the Nile League for sponsorship purposes, after the addition of title sponsor Nile Developments, is a professional association football league in Egypt and the highest division of Egyptian football league system. The league comprises 18 teams and operates on a system of promotion and relegation with the Egyptian Second Division A. Seasons mostly run from August to May. Unlike most other leagues, games are played on all days of the week.