The 2020–21 KNVB Cup, for sponsoring reasons officially called the TOTO KNVB Beker, was the 103rd season of the annual Dutch national football cup competition. It commenced on 29 August 2020 with the first of two preliminary rounds, and concluded on 18 April 2021 with the final played at De Kuip in Rotterdam.

The KNVB Beker, branded as the TOTO KNVB Beker for sponsorship reasons, is a competition in the Netherlands organized by the Royal Dutch Football Association (KNVB) since 1898. It was based on the format of the English FA Cup. Outside the Netherlands, it is often referred to as the Dutch Cup. The tournament consists of all teams from the top four tiers of Dutch league football, as well as the 24 semi-finalists of the six KNVB District Cups. The finals of the tournament traditionally takes place in De Kuip, and has been held there every season since the 1989 final. The winners of the cup compete against the winners of the Eredivisie for the Johan Cruyff Shield, which acts as the curtain raiser for the following season.