The 2020–21 Persian Gulf Pro League were the 38th season of Iran's Football League and 20th as Persian Gulf Pro League since its establishment in 2001. Persepolis were the defending champions. The season featured 14 teams from the 2019–20 Persian Gulf Pro League and two new teams promoted from the 2019–20 Azadegan League: Mes Rafsanjan and Aluminium Arak.

The Persian Gulf Pro League, formerly known as the Iran Premier League, is the highest division of professional football in Iran. Each year, its top team becomes the Iranian football champion, and the two lowest finishers are relegated to Azadegan League.