The 2020–21 Tunisian Super Cup was the 17th edition of the Tunisian Super Cup. The match was contested by the 2020–21 Tunisian Ligue Professionnelle 1 champions, Espérance de Tunis and the Tunisian Cup winners, Club Sfaxien. The match took place at Stade Hammadi Agrebi in Tunis on 25 September 2021, Espérance de Tunis won the game 1–0.

Espérance Sportive de Tunis, known as ES Tunis or simply EST for short, and nicknamed “Mkashkha”, The Elder of Tunisian Clubs, the Blood and Gold Club and The Beast of Africa. is a Tunisian professional sports club. It was founded on 15 January 1919 in the Bab Souika neighborhood in Tunis, Tunisia. It has been active in the first Tunisian Professional League 1 since 1936, during which it played 63 seasons, except for the 1970–71 season.