The 2020 Toyota 500 was a NASCAR Cup Series race held on May 20, 2020, at Darlington Raceway in Darlington, South Carolina, replacing Richmond Raceway's Toyota Owners 400. Contested over 208 laps—shortened from 228 laps due to rain, on the 1.366-mile (2.198 km) egg-shaped oval, it was the sixth race of the 2020 NASCAR Cup Series season and the 57th edition of the event.

Darlington Raceway is a race track built for NASCAR racing located in Darlington, South Carolina. It is nicknamed "The Lady in Black" and "The Track Too Tough to Tame" by many NASCAR fans and drivers and advertised as "A NASCAR Tradition." It is of a unique, somewhat egg-shaped design, an oval with the ends of very different configurations, a condition which supposedly arose from the proximity of one end of the track to a minnow pond the owner refused to relocate. This situation makes it very challenging for the crews to set up their cars' handling in a way that will be effective at both ends.