The 2021–22 First Professional Football League, also known as efbet League for sponsorship reasons, was the 98th season of the top division of the Bulgarian football league system, the 74th since a league format was adopted for the national competition of A Group as a top tier of the pyramid, and also the 6th season of the First Professional Football League, which decides the Bulgarian champion. Ludogorets Razgrad were the defending champions for the 10th consecutive time. They clinched their 11th title with four games to spare on 17 April 2022, following a 4–1 home win over Slavia Sofia.

Professional Football Club Ludogorets 1945, commonly known as Ludogorets Razgrad or simply Ludogorets, is a Bulgarian professional association football club based in Razgrad, which currently competes in the First Professional Football League, the top tier of the Bulgarian football league system.