The 2021 AFL Women's Grand Final was an Australian rules football match held at the Adelaide Oval on 17 April to determine the premiers of the fifth season of the AFL Women's (AFLW) competition. The match was contested by the Adelaide Crows and Brisbane Lions. It was the second grand final between the two clubs after the 2017 Grand Final which was won by Adelaide. Both clubs were appearing in their third grand final, following Adelaide's premierships in 2017 and 2019, and Brisbane's losses in the 2017 and 2018 grand finals.

The Adelaide Football Club, nicknamed the Crows, is a professional Australian rules football club based in Adelaide, South Australia that was founded in 1990. The Crows have fielded a men's team in the Australian Football League (AFL) since 1991, and a women's team in the AFL Women's (AFLW) competition since 2017. The club's offices and training facilities are located in the western Adelaide suburb of West Lakes, at the site of the club's former home ground Football Park. Since 2014 Adelaide have played home matches at the Adelaide Oval, a 53,500-seat stadium located on the northern bank on the River Torrens in North Adelaide.