The women's overall in the 2021 FIS Alpine Skiing World Cup involved 31 events in 5 disciplines: downhill (DH), Super-G (SG), giant slalom (GS), slalom (SL), and parallel (PAR). The sixth discipline, Alpine combined (AC), had all three of its events in the 2020–21 season cancelled, The tentative women's season schedule included 37 events, but the final women's schedule cut the number of events to 34 due to the continuing disruption cased by the COVID-19 pandemic. Among the changes were the elimination of the three Alpine combined races to eliminate the mixing of speed skiers and technical skiers in those events, as well as the elimination of two of the three parallels in favor of other races. Ultimately, only three of the races in this schedule -- one downhill, one Super-G, and one giant slalom -- were canceled during the season, as discussed later.

Petra Vlhová is a Slovak World Cup alpine ski racer who specialises in the technical events of slalom and giant slalom. Vlhová won the World Cup overall title in 2021 and the gold medal in the 2022 Winter Olympics in the slalom event, becoming the first Slovak skier to achieve these feats.