The 2021 Buffalo mayoral election was held on November 2, 2021. Democratic Mayor Byron Brown won his fifth term in office as a write-in candidate. Brown's victory marked the first time since 1985 that Buffalo did not elect the Democratic nominee for mayor.

Carl Pasquale Paladino is an American businessman and political activist. Paladino is the chairman of Ellicott Development Co., a real estate development company he founded in 1973.