The 2021 CAF Women's Champions League, known as the 2021 TotalEnergies CAF Women's Champions League for sponsorship purposes, was the inaugural edition of the annual African women's association football club tournament organized by CAF. It was held in Cairo, Egypt from 5 to 19 November 2021.

Mamelodi Sundowns Ladies F.C. is a women's professional soccer club based in Pretoria, South Africa. The team competes in the SAFA Women's League, the top tier women's football league in South Africa. They are the most successful women's team in South Africa with six titles. The team, together with the men's team are owned by Patrice Motsepe.